Finally, a Good Night's Sleep!

Biotest^®'s Z-12™ provides a full night's sleep without the sleep "hangover" associated with virtually all other prescription or non-prescription sleep aids.
Z-12™ is also useful to people who might not generally have trouble sleeping, but who might occasionally need a guarantee of a good night's rest, like the night before an exam, a job interview, or athletic meet.

Travelers might find it useful, too, in overcoming the first-night insomnia that often afflicts those who sleep in beds they're not accustomed to.
And Z-12™ is helpful for making an anxiety-packed day a lot more tolerable.

Z-12™ can also be used during waking hours for temporary relief of nervousness or anxiety without impairing brain function. Just one capsule helps to calm you down without impeding work performance in the slightest, and in fact, can allow users to focus better.

Z-12™ is an encapsulated, non-addictive formula that contains three anxiety reducing, sleep-inducing ingredients:

1. 4-amino-3-phenyl-butanoic acid HCL (PhGABA)
2. L-theanine
3. 5-hydroxytryptophan (5-HTP)

PhGABA is the main workhorse in Z-12™. The compound is a derivative of the inhibitory neurotransmitter GABA. When we're stressed, our brains experience an uninterrupted flow of stimulatory neurotransmitters and this causes restlessness, irritability, and insomnia.
GABA, and compounds related to it like the PhGABA in Biotest^®'s Z-12™, inhibit the flow of these stimulatory neurotransmitters, thereby allowing the brain and body to relax. PhGABA not only acts like GABA, but it also causes the release of GABA for a one-two sleep-inducing punch.

There's also evidence that PhGABA has serotonergic effects, too. (Serotonin is a neurotransmitter involved in sleep and feelings of well-being). There have been a ton of studies on PhGABA and many of them have compared the compound to Valium, which has pronounced anxiolytic (anxiety-reducing) properties, and the nootropic compound piracetam, which has weaker anxiolytic properties. In parts of Europe, the compound is used to treat post-traumatic stress disorder, stuttering, and of course, insomnia.

Furthermore, double-blind studies found the compound to increase intellectual function, improve physical strength, and reduce fatigue in neurotic patients. While it's not commonly known as a performance-enhancing supplement, PhGABA has been shown to improve work capacity in humans, along with increasing the performance of animals on swim tests.

PhGABA is an amazingly safe compound. Unlike many compounds, it seems to have no known negative side effects. In fact, it's even been found to have cardioprotective properties. The plasma half-life of a 250 mg dose of PhGABA is 5.3 hours, and most of the compound is excreted unchanged.

5-HTP (5-hydroxytryptophan) is a naturally occurring amino acid that's a precursor to the neurotransmitter serotonin (5-hydroxytryptamine), which is implicated in sleep and general feelings of well-being. When blood levels of 5-HTP are high, it causes the brain's serotonin producing neurons to increase production.
Furthermore, we believe that 5-HTP, in addition to being serotonergic, actually "resets" (normalizes) the hypothalamic-pituitary-adrenal (HPA) axis. In addition to helping the body adapt better to stress, this resetting effect also helps PhGABA and L-theanine to keep on working without allowing the user to develop tolerance.

L-Theanine is an amino acid found in green tea. Due to it promoting brain alpha-wave function, L-theanine facilitates a calm, relaxed-mental state. Animal studies suggest it increases brain serotonin and GABA levels, along with perhaps being both a neuroprotective agent and a cognitive enhancing agent. While there's some functional overlap between the three compounds in Z-12™, all affect the brain slightly differently and the three seem to work synergistically.

PhGABA is an amazingly safe compound. No signs of toxicity have been reported, and side effects are almost non-existent. The same is true of 5-HTP and L-theanine.

Time to feel normal again, time to feel good again. If you want a good night's rest or you're just too wired, it's time to try Z-12™.

References:

CNS Drug Rev. 2001 Winter;7(4):471-81. Phenibut: a tranquilizer and nootropic drug. Lapin I.

Am J Physiol Gastrointest Liver Physiol. 2001 Aug;281(2):G311-5. Receptors and transmission in the brain-gut axis: potential for novel therapies. IV. GABA(B) receptors in the brain-esophageal axis. Blackshaw LA.

Farmakol Toksikol. 1985 Jul-Aug;48(4). Differences and similarity in the interaction of fenibut, baclofen, and diazepam with phenylethylamine. Lapin IP.

Pavlov J Biol Sci. 1986 Oct-Dec21(4):129-40. On neurotransmitter mechanisms of reinforcement and internal inhibition. Shulgina GI.

Farmakol Toksikol. 1989 Jul-Aug;52(4):37-9. Effect of fenibut on seduxen on fetal development in the second half of pregnancy. Filimonov, VG, et al.

General

Serving Size

2 Capsules

Other

Z-12™ complex (4-amino-3-phenylbutyric acid HCl, L-theanine, 5-hydroxytryptophan)

1200 mg

Ingredients:

Other (inactive) ingredients: Gelatin, Microcrystalline cellulose, Magnesium stearate. Allergy information: Contains Gelatine (capsule).